Paul B Watkins Selected Research

Chemical and Drug Induced Liver Injury

1/2022	Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling.
1/2021	Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug Regimens.
1/2021	Human Leukocyte Antigen B14:01 and B35:01 Are Associated With Trimethoprim-Sulfamethoxazole Induced Liver Injury.
10/2020	Polygenic architecture informs potential vulnerability to drug-induced liver injury.
10/2020	HLA associations with infliximab-induced liver injury.
1/2020	Next-Generation DILI Biomarkers: Prioritization of Biomarkers for Qualification and Best Practices for Biospecimen Collection in Drug Development.
1/2020	Mechanistic Investigations Support Liver Safety of Ubrogepant.
11/2019	Shared Genetic Risk Factors Across Carbamazepine-Induced Hypersensitivity Reactions.
8/2019	Genetic Polymorphisms Implicated in Nonalcoholic Liver Disease or Selected Other Disorders Have No Influence on Drug-Induced Liver Injury.
7/2019	Novel Mechanisms of Valproate Hepatotoxicity: Impaired Mrp2 Trafficking and Hepatocyte Depolarization.

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Paul B Watkins Research Topics

Disease

52	Chemical and Drug Induced Liver Injury 01/2022 - 01/2005
8	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 08/2014
7	Necrosis 01/2020 - 06/2014
6	Liver Diseases (Liver Disease) 01/2020 - 11/2008
5	Neoplasms (Cancer) 11/2020 - 02/2005
4	Migraine Disorders (Migraine) 01/2022 - 11/2010
4	Autosomal Dominant Polycystic Kidney (ADPKD) 01/2021 - 11/2015
4	Type 2 Diabetes Mellitus (MODY) 01/2019 - 01/2018
3	Epilepsy (Aura) 12/2019 - 11/2010
3	Acute Liver Failure (Fulminant Hepatic Failure) 01/2019 - 01/2013
3	Jaundice (Icterus) 01/2018 - 01/2005
3	Tuberculosis (Tuberculoses) 01/2017 - 03/2014
2	Wounds and Injuries (Trauma) 01/2019 - 01/2018
2	Liver Failure 01/2019 - 01/2018
2	Poisoning 01/2018 - 08/2012
2	Hyponatremia 01/2017 - 11/2015
2	Infections 08/2014 - 12/2008
2	Genetic Predisposition to Disease (Genetic Predisposition) 07/2011 - 03/2008
2	Osteomalacia 06/2006 - 01/2006
1	Myoclonic Epilepsies (Myoclonic Encephalopathy) 01/2021
1	Multiple Trauma (Multiple Injuries) 10/2020
1	Bacterial Pneumonia 01/2020
1	Syncope (Fainting) 01/2020
1	Drug-Related Side Effects and Adverse Reactions 01/2020
1	Myasthenia Gravis 01/2020
1	Headache (Headaches) 12/2019
1	Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular) 12/2019
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 12/2019
1	Pneumonia (Pneumonitis) 12/2019
1	Stevens-Johnson Syndrome (Lyell's Syndrome) 11/2019
1	Hypersensitivity (Allergy) 11/2019
1	Cicatrix (Scar) 11/2019
1	Non-alcoholic Fatty Liver Disease 08/2019
1	Bacterial Infections (Bacterial Infection) 02/2019
1	End Stage Liver Disease 01/2019
1	Acute-Phase Reaction 01/2018
1	2 Gingival Fibromatosis 01/2018

Drug/Important Bio-Agent (IBA)

29	Pharmaceutical PreparationsIBA 01/2021 - 01/2003
16	Biomarkers (Surrogate Marker)IBA 10/2020 - 11/2008
9	Bile Acids and Salts (Bile Acids)IBA 01/2022 - 01/2013
8	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2020 - 08/2012
8	Dyphylline (Diprophylline)FDA Link 01/2019 - 01/2005
6	Tolvaptan FDA Link 01/2021 - 11/2015
6	Alanine Transaminase (SGPT)IBA 01/2020 - 01/2005
4	TAK-875IBA 01/2019 - 01/2018
4	BilirubinIBA 01/2018 - 03/2011
4	Cytochrome P-450 CYP3AIBA 06/2006 - 09/2003
3	Calcitonin Gene-Related Peptide Receptor AntagonistsIBA 01/2022 - 12/2019
3	Calcitonin Gene-Related PeptideIBA 01/2022 - 12/2019
3	Isoniazid (Ftivazide)FDA LinkGeneric 01/2021 - 10/2008
3	Transaminases (Aminotransferases)IBA 12/2019 - 11/2015
3	EnzymesIBA 02/2019 - 03/2014
3	CytokinesIBA 01/2019 - 01/2013
3	Member 11 Subfamily B ATP Binding Cassette TransporterIBA 11/2018 - 01/2013
3	Keratin-18 (Keratin 18)IBA 11/2017 - 03/2014
3	MicroRNAs (MicroRNA)IBA 01/2017 - 06/2014
2	telcagepantIBA 01/2022 - 01/2020
2	Immune Checkpoint InhibitorsIBA 11/2020 - 01/2019
2	telithromycin (Ketek)FDA Link 01/2020 - 02/2019
2	MacrolidesIBA 01/2020 - 02/2019
2	K-18 conjugate (K18)IBA 01/2019 - 11/2017
2	Proteins (Proteins, Gene)FDA Link 01/2015 - 01/2013
2	L-Iditol 2-Dehydrogenase (L Iditol 2 Dehydrogenase)IBA 08/2014 - 06/2014
2	Glutamate DehydrogenaseIBA 08/2014 - 06/2014
2	Alkaline PhosphataseIBA 07/2014 - 03/2011
2	Amoxicillin (Wymox)FDA LinkGeneric 07/2011 - 10/2008
2	Clavulanic Acid (Potassium Clavulanate)FDA LinkGeneric 07/2011 - 10/2008
2	Valproic Acid (Depakote)FDA LinkGeneric 11/2010 - 10/2008
1	CannabidiolIBA 01/2021
1	Trimethoprim (Proloprim)FDA LinkGeneric 01/2021
1	Thymidine Monophosphate (TMP)IBA 01/2021
1	Sulfamethoxazole FDA LinkGeneric 01/2021
1	Infliximab (Remicade)FDA Link 10/2020
1	2- (8- (3,5- difluorophenyl)- 10- oxo- 6,9- diazaspiro(4.5)dec- 9- yl)- N- (2'- oxo- 1,1',2',3- tetrahydrospiro(indene- 2,3'- pyrrolo(2,3- b)pyridin)- 5- yl)acetamideIBA 01/2020
1	solithromycinIBA 01/2020
1	PF-04895162IBA 12/2019
1	Protein Isoforms (Isoforms)IBA 12/2019
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 12/2019
1	idelalisibIBA 12/2019
1	ubrogepantIBA 12/2019
1	Carbamazepine (Tegretol)FDA LinkGeneric 11/2019
1	HLA-A31 antigenIBA 11/2019
1	HLA-B57 antigenIBA 11/2019
1	HLA Antigens (Human Leukocyte Antigens)IBA 08/2019
1	Anti-Bacterial Agents (Antibiotics)IBA 02/2019
1	bile acid binding proteinsIBA 02/2019
1	Sitagliptin Phosphate (Januvia)FDA Link 01/2019
1	glimepiride (Amarel)FDA LinkGeneric 01/2019
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2019
1	XenobioticsIBA 01/2019
1	antineoplaston A10 (A 10)IBA 01/2018
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2018
1	Taurocholic Acid (Sodium Taurocholate)IBA 01/2018
1	cimaglerminIBA 01/2018
1	CaspasesIBA 11/2017
1	Troglitazone (Rezulin)FDA Link 02/2017
1	Vasopressin Receptors (Arginine Vasopressin Receptor)IBA 01/2017

Therapy/Procedure

3	Liver Transplantation 01/2019 - 07/2014
2	Therapeutics 01/2019 - 01/2005
1	Aftercare (After-Treatment) 10/2020